245 Metabolomic biomarkers for preeclampsia prediction
نویسندگان
چکیده
منابع مشابه
Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers.
Preeclampsia is a pregnancy-specific syndrome that causes substantial maternal and fetal morbidity and mortality. The etiology is incompletely understood, and there is no clinically useful screening test. Current metabolomic technologies have allowed the establishment of metabolic signatures of preeclampsia in early pregnancy. Here, a 2-phase discovery/validation metabolic profiling study was p...
متن کاملPregnancy/Preeclampsia Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers
Preeclampsia is a pregnancy-specific syndrome that causes substantial maternal and fetal morbidity and mortality. The etiology is incompletely understood, and there is no clinically useful screening test. Current metabolomic technologies have allowed the establishment of metabolic signatures of preeclampsia in early pregnancy. Here, a 2-phase discovery/validation metabolic profiling study was p...
متن کاملValidation of metabolomic models for prediction of early-onset preeclampsia.
OBJECTIVE We sought to perform validation studies of previously published and newly derived first-trimester metabolomic algorithms for prediction of early preeclampsia (PE). STUDY DESIGN Nuclear magnetic resonance-based metabolomic analysis was performed on first-trimester serum in 50 women who subsequently developed early PE and in 108 first-trimester controls. Random stratification and allo...
متن کاملMetabolomic Biomarkers in Serum and Urine in Women with Preeclampsia
OBJECTIVE To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis. METHODS Urine and serum samples from pregnant women with preeclampsia (n = 10), normal pregnancies (n = 10) and non-pregnant women (n = 10) matched by age and gestational age were analyzed with MR spectrosc...
متن کاملPrediction of preeclampsia by biomarkers: A review of literature
Preeclampsia is a leading cause of maternal and perinatal mortality and morbidity internationally. The aetiology of this disease is unknown, though widespread endothelial dysfunction is considered to be the major reason. Early identification of this disease would be helpful in early identification of the high risk patients, diagnosis and better prenatal care. Several biomarkers either individua...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2021
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2020.12.267